钟文婉

主要研究方向与成果：

主要研究方向包括：
  1）发展体外检测技术以实现对靶标分子的高通量快速分辨；
  2）创新分离技术以辅助通过分子组学研究来发现新的疾病预测与监控的途径；
  3）研究纳米-生物界面，深入了解纳米生物冠的形成及其对纳米材料毒性的调控机理；
  4）研究分子间相互作用，指导设计主客体传感阵列，并运用机器学习的手段，准确辨别生物大分子细微的结构变化，从而加深对其结构与功能间相互关系的理解。
  研究工作在Nature Chemistry, Journal of American Chemical Society, Angewandte Chemie International Edition, Nucleic Acids Research, Chemical Sciences, Environmental ScienceTechnology, Analytical Chemistry等国际权威期刊上发表。钟文婉教授曾获美国国家自然科学基金的Career Award，及加州大学河滨分校的Chancellor's Award for Excellence in Undergraduate Research。持续担任美国国家自然科学基金，美国国家卫生研究院，及香港研究资助局的基金评审员，并为多个重要学术期刊审稿。参与组织并主持了多个国际会议生化分析分会。

代表性论文：

[1] Yue Yuan, Congxiao Wang, Shreyas Kuddannaya, Jia Zhang, Dian R. Arifin, Zheng Han, Piotr Walczak, Guanshu Liu, and Jeff W. M. Bulte*. In vivo tracking of unlabelled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI. Nature Biomedical Engineering2022, 6, 658-666.

[2] Yue Yuan, Jia Zhang, Xiaoliang Qi, Shuoguo Li, Guanshu Liu, Soumik Siddhanta, Ishan Barman, Xiaolei Song, Michael T. McMahon, Jeff W.M. Bulte*. Furin-Mediated lntracellular Self-Assembly of Olsalazine Nanoparticlesfor Enhanced MR Imaging and Tumor Therapy. Nature Materials2019, 18, 1376-1383.

[3] Chenchen Wang, Wei Du, Chenfan Wu, Shan Dan, Miao Sun, Tong Zhang, Bin Wang, Yue Yuan*, and Gaolin Liang*. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging. Angewandte Chemie International Edition2021, 61, e202114766.

[4] Yue Yuan, Piyush Raj, Jia Zhang, Soumik Siddhanta, Ishan Barman*, Jeff W. M. Bulte*. Furin‐Mediated Self‐Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors. Angewandte Chemie International Edition2021, 60, 3923-3927.

[5] Yue Yuan, Zhiliang Wei, Chengyan Chu, Jia Zhang, Xiaolei Song, Piotr Walczak, Jeff W. M. Bulte*. Developing Zinc-Specific iCEST MRI as Imaging Biomarker for Prostate Cancer. Angewandte Chemie International Edition2019, 58, 15512-15517.