黄光明

主要研究方向与成果：

主要从事质谱分析方法研究及其在生物大分子和代谢相关小分子的分析中的应用研究。其从事的单细胞分析新技术的研究，一直都是生命科学领域重点关注的焦点之一。我们发展了伴随电喷雾过程的毫秒级别电泳分离技术，进一步整合了低流速电喷雾技术，并兼容膜片钳技术，搭建了单细胞代谢质谱分析平台，最终实现多个代谢物的同时非靶向高灵敏检测，解决了相关领域的一系列技术难题，为生命科学等领域的研究提供了新的表征方法。

代表性论文：

[1]  Hongying Zhu; Ning Wang; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*; Wei Xiong*; Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain, Cell, 2018, 173(7): 1716-1727.

[2]  Hongying Zhu; Guichang Zou; Ning Wang; Meihui Zhuang; Wei Xiong*; Guangming Huang*; Single-neuron identification of chemical constituents, physiological changes and metabolism using mass spectrometry, PNAS, 2017, 114(10): 2586-2591.

[3]  Yuting Chen; Gongyu Li; Siming Yuan; Yang Pan; Yangzhong Liu; Guangming Huang*; Ultrafast Microelectrophoresis: Behind Direct Mass Spectrometry Measurements of Proteins and Metabolites in Living Cell/Cells , Analytical Chemistry, 2019, 91(16): 10441-10447.

[4]  Gongyu Li; Shihui Zheng; Yuting Chen; Zhuanghao Hou; Guangming Huang*; Reliable Tracking In-Solution Protein Unfolding via Ultrafast Thermal Unfolding/Ion Mobility-Mass-Spectrometry, Analytical Chemistry, 2018, 90(13): 7997-8001.