姓名:胡祥龙
职称:特任教授
单位:中国科学技术大学
邮箱:huxlong@ustc.edu.cn
研究方向： i)生物医药关键组分与药物递送技术开发，如聚前药/高分子前药、脂质体、脂质纳米粒子、蛋白偶联药物等；ii)生物医学诊疗方案开发，如肿瘤、衰老、疼痛、感染与炎症等。iii)功能高分子材料应用开发，如聚氨酯、功能涂层材料等。针对大部分小分子药物水溶性一般、副作用显著等挑战，发展了一种普适性的药物递送策略，即“聚前药polyprodrug”技术，实现药物递送系统“载得多、运得稳、送得准、看得见”，取得系列成果，聚前药技术已经引发基础研究兴趣与产业跟进。以第一/通讯作者发表SCI论文50余篇，论文总引用7000余次，研究论文单篇最高他引500余次，H指数44；获授权中国发明专利10余项。
1. Jiajia Tan, Jiqian Zhang, Minglong Chen, Jie Cen, Wenli Wang, Chengying You, Xianglong Hu*, Jinming Hu*, Shiyong Liu* “Meltable Polycarbonate Polymersomes as Photoresponsive Micro‐Analgesia Pumps for Concurrent Tumor Therapy and Pain Relief” Angewandte Chemie-International Edition 2026, 65, e22563.
2. Chengzhou Song, Minglong Chen, Jiajia Tan, Jie Xu, Yuben Zhang, Guoying Zhang, Xianglong Hu*, Shiyong Liu* “Self-Amplified Cascade Degradation and Oxidative Stress Via Rational pH Regulation of Oxidation-Responsive Poly(ferrocene) Aggregates” Journal of the American Chemical Society 2023, 145, 17755-17766.
3. Wenhui Wang, Yongteng Zhang, Zeshu Wang, Xueping Liu, Siyu Lu, Xianglong Hu* A Native Drug-Free Macromolecular Therapeutic to Trigger Mutual Reinforcing of Endoplasmic Reticulum Stress and Mitochondrial Dysfunction for Cancer Treatment ACS Nano 2023, 17, 11023-11038.
4. Jie Xu, Jiajia Tan, Chengzhou Song, Guoying Zhang, Xianglong Hu*, Shiyong Liu* Self‐Immolative Amphiphilic Poly (ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy Angewandte Chemie-International Edition 2023, 62, e202303829. (VIP paper, highlighted by Wiley Press Release and Newswise, respectively)
5. Zhixiong Wang, Meixiao Zhan, Weijie Li, Chengyan Chu, Da Xing*, Siyu Lu, Xianglong Hu* “Photoacoustic Cavitation-Ignited Reactive Oxygen Species to Amplify Peroxynitrite Burst by Photosensitization-free Polymeric Nanocapsules” Angewandte Chemie-International Edition 2021, 60, 4720-4731. (“ESI Highly Cited Paper”)