聚焦于人工智能（AI）赋能光学功能晶态多孔材料（MOF、COF、HOF等）的精准智能创制，并探索其在生命健康、能源转换等领域的应用。主要研究方向包括：(1) 精准化、智能化双驱动的AIE COF材料的精准智能创制及机制研究；(2) AI赋能优异光物理性质（如光致、电致、压致、力致发光、室温磷光及多光子荧光等）晶态多孔材料（MOF、COF、HOF等）精准智能创制；(3)AI赋能功能和应用导向的MOF、COF、HOF等材料的个性化定制、规模化、标准化、大批量制备及其在生命健康、能源转换等领域的应用。共发表 SCI 论文 30 余篇，以第一作者和通讯作者 (含共同) 共发表影响因子 > 10 的论文 17 篇，其中包含 Nat. Commun. (2), J. Am. Chem. Soc. (1), Angew. Chem. Int. Ed. (2), Adv. Mater. (3), Chem (1), Matter (1), Adv. Funct. Mater. (3), Nano Letter (1), Bioact. Mater. (1), Aggregate (1), Green Energy & Environment (1) 等，其中 4 篇论文入选 ESI 高被引论文，1 篇入选 ESI 热点论文。
[1] Liang Zhang#, Shuo Wang#, Qi-Chao Yang#, An Song, Yuan-Yuan Wang, Wen-Da Wang, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun*, Hexiang Deng*, “Bimetallic Covalent Organic Framework Trigger PANoptosis for Efficient Radiotherapy” Adv. Mater. 2025, 37, 2413002.
[2] Liang Zhang#, Boxin Zhang#, Meng-Jie Zhang#, Wenlang Li, Hao Li, Yantian Jiao, Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Hai-Tao Feng, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Ben Zhong Tang*, Zhi-Jun Sun*, “Trigger Inducible Tertiary Lymphoid Structure Formation using Covalent Organic Frameworks for Cancer Immunotherapy” Nat. Commun. 2025, 16, 1-14.
[3] Liang Zhang#, An Song#, Qi-Chao Yang, Shu-Jin Li, Shuo Wang, Shu-Cheng Wan, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Hexiang Deng*, Ben Zhong Tang*, Zhi-Jun Sun*, “Integration of AIEgens into Covalent Organic Frameworks for Pyroptosis and Ferroptosis Primed Cancer Immunotherapy” Nat. Commun. 2023, 14, 5355.
[4] Liang Zhang#, Shu-Cheng Wan#, Jianyu Zhang#, Meng-Jie Zhang, Qi-Chao Yang, Boxin Zhang, Wu-Yin Wang, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Hexiang Deng*, Zhi-Jun Sun*, Ben Zhong Tang*, “Activation of Pyroptosis Using AIEgen-Based sp2 Carbon-Linked Covalent Organic Frameworks” J. Am. Chem. Soc. 2023, 145, 17689-17699.
[5] Liang Zhang#, Qi-Chao Yang#, Shuo Wang, Yao Xiao, Shu-Cheng Wan, Hexiang Deng*, Zhi-Jun Sun*, “Engineering Multienzyme-Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity” Adv. Mater. 2022, 34, 2108174.