| 姓名：石景 副教授 单位：中国科学技术大学 邮箱：shijing@ustc.edu.cn |
主要研究方向与成果：
主要从事有机化学和化学生物学方向研究。近年来以多肽药物、毒素多肽为目标，发展了一系列蛋白质化学合成新策略、新方法，实现了一系列活性多肽及其衍生物以及翻译后修饰蛋白质的高效合成，同时在功能蛋白质的化学合成及结构、功能研究方面也开展了系列工作。
代表性论文：
[1] Ling Xu, Jian Fan, Yu Wang, Zhongping Zhang, Yao Fu, Yi-Ming Li,* Jing Shi,* An activity-based probe developed by a sequential dehydroalanine formation strategy targets HECT E3 ubiquitin ligases, Chem. Commun.2019, 55, 7109-7112.
[2] Rui Zhao, Pan Shi, Junyou Chen, Jing Shi,* Donald Bierer, Lei Liu, Yi-Ming Li,* Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Chem. Sci.2020, 11, 7927-7932.[3] Yu Wang, Chenchen Chen, Xianbin Meng, Jing Shi,* Lei Liu, Yi-Ming Li,* Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO Chain-Specific Interacting Proteins, CCS Chem.2020, 2, 1157-1168.
[4] Rui Zhao, Pan Shi, Ji-bin Cui, Mark Meininghaus, Donald Bierer, Jing Shi,* Yi-Ming Li,* Lei Liu,* Single-Shot Solid-Phase Synthesis of Full-Length H2 Relaxin Disulfide Surrogates, Angew. Chem. Int. Ed.2023, e202216365.
[5] Xiao Hua, Yanyanc Guo, Yu Wang, Guochao Chu, Pincheng Li, Jing Shi,* Acyl azide modification of the ubiquitin C-terminus enables DUB capture, Chem Commun.2023, 59, 1333-1336.